Because Science.
Lasseigne Lab
Computational Biology
Recent posts
New Publication in Cancer Reports! Inferring chromosomal instability from copy number aberrations as a measure of chromosomal instability across human cancers
New Publication in Molecular Medicine! Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion
New Publication in Briefings in Functional Genomics! Quantifying transcriptome diversity Review
CoSIA R Bioconductor package and Shiny app for CrOss Species Investigation and Analysis (Preprinted & Under Review; available on Bioconductor)
Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes (Preprinted & Under Review)
Signature reversion of three disease-associated gene signatures prioritizes cancer drug repurposing candidates (Preprinted & Under Review)
Computational Advancements in Drug Repurposing for Cancer Combination Therapy Prediction (Preprinted & Under Review)
Evaluating cancer cell line and patient-derived xenograft recapitulation of tumor and non-diseased tissue gene expression profiles (Preprinted & In Revision)
Inferring chromosomal instability from copy number aberrations as a measure of chromosomal instability across human cancers (Preprinted & Under Review)
New Publication in PeerJ! CINmetrics an R package for analyzing copy number aberrations as a measure of chromosomal instability (CINmetrics is available on CRAN)
New Publication in PLOS Computational Biology! Ten simple rules for using public biological data for your research
Chromosomal Instability and PKD Drug Repurposing Preprints
