Lasseigne Lab

Lasseigne Lab

Because Science.

Integrative analysis of genomic data in complex disease

Understanding mechanisms associated with broad molecular changes in complex disease

Integration Figure

As a postdoctoral fellow, Brittany lead and/or participated in several projects aimed at understanding the mechanisms behind broad molecular changes (e.g., thousands of differentially expressed genes between normal and disease tissues). For example, she and her colleagues identified transcription factor binding sites with altered DNAm in prostate cancer and genomic regulation of triple negative breast cancer invasion. Likewise, by measuring relative cell proliferation from gene expression data across 19 cancers, they demonstrated cell proliferation is a major driver of gene expression variation, is strongly associated with clinical characteristics, and by stratifying on cell proliferation, improved predictive models of patient survival. Additionally, they analyzed gene expression and metabolite changes in psychiatric disease and found that while disease differences were heterogeneous across disease samples, they were highly correlated with transcripts previously identified as specific to brain cell types. Many of these analyses utilize machine learning techniques.

Associated Publications

Post-mortem molecular profiling of three psychiatric disorders

RNA sequencing-based cell proliferation analysis across 19 cancers identifies a subset of proliferation-informative cancers with a common survival signature

Genome-wide DNA methylation measurements in prostate tissues uncovers novel prostate cancer diagnostic biomarkers and transcription factor binding patterns

Genomic regulation of invasion by STAT3 in triple negative breast cancer

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