Publications

. Regional collapsing of rare variation implicates specific genic regions in ALS. bioRxiv, 2018.

Preprint Project

. The role of DNA methylation in renal cell carcinoma. Molecular Diagnosis & Therapy (Invited Review), 2018.

PDF Project

. Genome-wide analyses identify KIF5A as a novel ALS gene. Neuron, 2018.

PDF Project

. Post-mortem molecular profiling of three psychiatric disorders. Genome Medicine, 2017.

Preprint PDF Dataset Project Poster

. aRNApipe: a balanced, efficient and distributed pipeline for processing RNA-seq data in high-performance computing environments. Bioinformatics, 2017.

Preprint PDF Code Project

. Genome-wide DNA methylation measurements in prostate tissues uncovers novel prostate cancer diagnostic biomarkers and transcription factor binding patterns. BMC Cancer, 2017.

PDF Dataset Project

. Genomic regulation of invasion by STAT3 in triple negative breast cancer. Oncotarget, 2017.

PDF Dataset Project

. Kinase gene expression profiling of metastatic clear cell renal cell carcinoma tissue identifies potential new therapeutic targets. PLoS One, 2016.

PDF Dataset Project

. Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science, 2015.

PDF Project Slides

. DNA methylation profiling reveals novel diagnostic biomarkers in renal cell carcinoma. BMC Medicine, 2014.

PDF Project Poster Slides

Projects

Biomarker discovery in kidney cancer

Discovery of kidney cancer diagnostic biomarkers and therapeutic signatures

Causal variant identification in neurodegenerative disease

Identification of causal variants and genes in neurodegenerative disease

Computational Tools

Developing computational tools to share with the research community

Integrative analysis of genomic data in complex disease

Understanding mechanisms associated with broad molecular changes in complex disease

Recent Teaching and Science Outreach

I am passionate about both science education and community outreach at all levels.

Here are some of my recent efforts:

Contact