Our research focuses on developing approaches for assaying and integrating omics data, functional annotations, and patient information to discover novel mechanisms in disease etiology and progression, therapeutic targets, and circulating biomarkers.
Current Members
Alumni
Furry Friends
Current Members
Brittany Lasseigne, PhD
Principal Investigator and Assistant Professor
Dr. Lasseigne is an Assistant Professor in the Department of Cell, Developmental and Integrative Biology, an Associate Scientist in both the O’Neal Comprehensive Cancer Center Experimental Therapeutics Program and the Center for Clinical and Translational Science, and a Scientist in both the Informatics Institute and the Hugh Kaul Precision Medicine Institute at the University of Alabama at Birmingham. She previously completed a BS in Biological Engineering at Mississippi State University, an interdisciplinary biology, chemistry, and chemical engineering PhD in Biotechnology Science and Engineering from The University of Alabama in Huntsville, and a postdoctoral fellowship in genetics and genomics at the HudsonAlpha Institute for Biotechnology. Brittany is passionate about developing and applying genomics technologies to human diseases and teaching data science to students and scientists of all backgrounds.
Brittany's Publications and Grants
bnp0001[@]uab.edu
Amanda Clark, PhD
Postdoctoral Fellow
Amanda is an IRACDA-MERIT Postdoctoral Fellow at the University of Alabama at Birmingham. She completed a B.S. in Molecular Biology at UAB and a PhD in Biology at Auburn University. Amanda is passionate about integrating computational thinking and data science into undergraduate biology education, the evolutionary dynamics of complex systems, and comparative multi-omics for human disease modeling.
Emma Jones
Graduate Research Assistant
Emma is a current PhD student in the Genomics, Genetics, and Bioinformatics theme within the UAB Graduate Biomedical Sciences program, and is also a UAB Neuroscience Roadmap Scholar. She graduated in 2019 with a B.A. in Psychology and a minor in Studio Art from California State Polytechnic University, Humboldt in Arcata, California. Emma has a research background in psychology, neuroscience, cellular and molecular biology, and genomics. She is currently building on those skills by working on the best way to study transcriptional diversity in the brain, and how changes in diversity at the isoform level can relate to disease.
Jen Fisher
Graduate Research Assistant
Jen is a current PhD student in the Genomics, Genetics, and Bioinformatics theme within the UAB Graduate Biomedical Sciences program. She is supported by UAB’s AMC21 Scholars program. In 2019, she earned a B.S. in Biological Engineering with a minor in Mathematics from Mississippi State University. Jen is currently developing machine learning and network approaches to improve drug repurposing candidate selection and avoiding side effects due to sex differences. She is applying her methods in two rare diseases: Friedreich’s Ataxia & Glioblastoma multiforme.
Jordan Whitlock
Graduate Research Assistant
Jordan is a current PhD student in the Genetics, Genomics and Bioinformatics theme within the UAB Graduate Biomedical Sciences program. She has a B.S. in Genetics and Genomic Sciences from UAB. Her projects and interests focus on developing and applying disease-agnostic computational approaches to understand the role of context dependency across and within disease. Jordan has a particular heart for rare diseases. She is currently investigating the role of cell-specificity in tissue-specific Mendelian disease manifestations. Using renal- and neurological-associated phenotypes as a test set, she is employing a combination of wet-lab and computational approaches involving expression and regulatory networks to identify the underlying drivers of Mendelian disease.
Lizzy Wilk
Researcher III
Lizzy earned her B.S. in Biology with a minor in Chemistry from the University of Alabama at Huntsville and M.S. in Biotechnology with a specialization in Bioinformatics from University of Maryland Global Campus. Prior to working at the University of Alabama at Birmingham, she applied genomics technologies such as RNA-Seq for understanding cancer and chemotherapy resistance as a research assistant. Lizzy currently works as a staff scientist, applying transfer learning and drug repurposing methods to gene expression data.
Tabea Soelter
Graduate Research Assistant
Tabea is a current PhD student and Alzheimer’s of Central Alabama (ACA) Lindy Harrell Predoctoral Scholar in the Genetics, Genomics and Bioinformatics theme within the UAB Graduate Biomedical Sciences program. She has a B.S. in Cell and Molecular Biology from Piedmont University. Tabea is currently investigating the cell-type-specific role of cell-cell communication between neuronal and non-neuronal cell populations in Alzheimer's disease using public human data. She is also interested in the effects of aging on the Alzheimer’s disease brain and therefore employs wet-lab and computational approaches to understand age-associated changes in cell-cell communication using her own mouse sequencing data across multiple timepoints.
TC Howton, PhD
Scientist I and Lab Manager
T.C. earned his PhD in Biology from the University of Alabama at Birmingham. During his doctoral studies, T.C. focused on using network-based approaches to elucidate the molecular interactions between plants and bacterial pathogens. T.C. is currently serving as a lab manager as well as research scientist within the Lasseigne lab.
Victoria Flanary
Graduate Research Assistant
Victoria is an MD/PhD graduate trainee in the UAB Medical Scientist Training Program. She graduated from UAB in 2020 with a B.S. in Neuroscience, along with minors in Biology and Chemistry. Her background in conducting translational research for glioblastoma has inspired her to pursue a scientific career aimed toward maximizing clinical therapies for various malignancies, primarily via utilizing computational genomic data to advance precision medicine for cancer.
Vishal H. Oza, PhD
Scientist II
Vishal is a Scientist II in the Department of Cell, Developmental and Integrative Biology at the University of Alabama at Birmingham Heersink School of Medicine. He got his PhD from University of Alabama, Tuscaloosa where he developed methods for constructing network models of Drosophila melanogaster metabolome from untargeted metabolomics data and integrating with genome and proteome, thus building a multilayered network model. His research interests include developing mathematical models using machine learning and network science to understand biological complexity.
Our Alumni
Nathaniel DeVoss
Undergraduate Research Assistant (2022-2023)
Currently: Undergraduate Student, University of Alabama at Birmingham
Anisha Haldar
Undergraduate Research Assistant (2021-2023)
Currently: Undergraduate Student, University of Alabama at Birmingham
Avery Williams
Undergraduate Research Assistant (2019-2023)
Currently: Graduate Student, Biomedical Sciences PhD Program, University of California, San Diego
Ryan Brownlee
Undergraduate Research Assistant / KURE Student (2022)
Currently: Undergraduate Student, Mercer University
Sasha Thalluri
Undergraduate Research Assistant (2019-2022)
Currently: Medical Student, Heersink School of Medicine, University of Alabama at Birmingham
Hannah Cleary
Undergraduate Research Assistant / KURE Student (2021)
Currently: Medical Student, University of Kentucky
Emily Page
Research Assistant / Grad PREP Scholar (2020-2021)
Currently: Graduate Student, Genetics, Genomics, and Bioinformatics, University of Alabama at Birmingham
Kasi McPherson, PhD
Postdoctoral Fellow (2020-2021)
Currently: Postdoctoral Fellow, University of Alabama at Birmingham
Drew Hardigan, PhD
Visiting Postdoctoral Fellow (2020)
Currently: Neurosurgery Resident, Duke University
Randi Wood
Researcher IV and Lab Manager (2019-2020)
Roshan Darji
Computational Biologist (2019)
Currently: Department of Biostatistics, Rollins School of Public Health, Emory University
Past Rotation Students
Jack Hoover (2020)
Shaurita Hutchins (2020)
Furry Friends
April Jones
Owner: Emma
Gotcha Day: April 10, 2018
Likes: Warm laps, cuddles, and routines
Dislikes: Strangers and closed doors
Fun Fact: Only has 3 legs!
Mango Flanary
Owner: Victoria
Birthday: May 10, 2021
Likes: Bathrooms, cheek scratches, cat tv
Dislikes: Long car rides
Bagley (Bag-boo) Florence Fisher
Owner: Jen
Gotcha Day: May 19th, 2020
Likes: Dog cookies, peanut butter, and balls
Dislikes: Rain and the dark
Lily (Lily Lou) Williams
Owner: Avery (Alum)
Gotcha Day: sometime in 2006
Likes: Licking windows, attention, and her catnip banana
Dislikes: Getting wet and vacuums
Mac Aroniandcheese Lasseigne (aka Mac)
Owners: The Lasseignes
Birthday: July 4, 2019
Likes: Exploring new places, people and their food
Methyl and Isla Thalluri
Owner: Sasha (Alum)
Birthday: 3.8-billion years ago
Likes: Outside
Dislikes: Hard headed people
Partho Oza
Owner: Vishal
Birthday: Jauary 19th, 2020
Likes: Playing fetch
Dislikes: Sitting idle
Peanut Junior (PJ) Soelter
Owner: Tabea
Birthday: August 4th, 2018
Likes: Sleeping in the sun, treats, and attention
Dislikes: Closed doors
Poirot Oza
Owner: Vishal
Birthday: August 18th, 2015
Likes: Exploring
Dislikes: Flies
Sadie Jones
Owner: Emma
Gotcha Day: September 15th, 2019
Likes: Playing fetch, butt rubs, and smelly shoes
Dislikes: Getting nails trimmed
Basil Jones
Owner: Emma
Gotcha Day: November 14, 2022
Likes: COMFY COUCHES AND GOING TO BED EARLY
Dislikes: CENTRAL HEATING TURNING ON
Fun Fact: Dances when she is happy
Sophie Howton
Owner: TC
Birthday: April 12th, 2010
Likes: Sleeping and treats
Dislikes: Cardboard boxes
William Soelter-Patterson
Owner: Tabea
Gotcha Day: Oct 6th, 2020
Likes: Food, toys, and his dog park friends
Dislikes: Rain and kids
Wrigley Whitlock
Owner: Jordan
Gotcha Day: September 15th, 2016
Likes: His Squeaky ball, hikes, and watching baseball
Dislikes: Being alone